Face Mask Embedded with Nanoemulsion for Reducing Facial Skin Adverse Effects Caused by Prolonged Wearing the Mask during COVID-19 Management

Abstract: Background: Wearing a facemask is one of the precautionary measures for preventing coronavirus disease spread, which causes many facial skin adverse effects. Vitamin-E (TPGS) and olive oil have an efficient effect on moistening. Therefore, in this study, face-masks embedded with NE; prepared using TPGS, were developed to reduce long-wearing face mask effect. Methods: Box-Behnken design was used develop NE formulations physically evaluated select most stable formulation. Fibroblast cell lines (3T3) examine efficacy dermal proliferation vitro cytotoxicity possibilities. Face-masks also examined 6 hr wearing compatibility healthy participants. Results: The formulated didn’t significantly affect nor had toxic cells (p<0.05). More than 60% respondents satisfied masks containing NE. Conclusion: In particular, preparaed selected formula could produce emollient feelings during application without retarding breathing or causing any irritant sensation. Keywords: Nanoemulsions, Face-mask, Coronavirus virus, Olive oil, Vitamin E.